Gene information
Official symbol GZMB
Official full name granzyme B
Gene type protein-coding gene
Chromosome14q12
Alias symbolCCPI; CGL-1; CSP-B; CGL1; CTSGL1; HLP; SECT
Previous symbolCTLA1; CSPB
Gene familyGranule associated serine proteases of immune defence
Resources
Entrez Gene 3002
HGNC HGNC:4709
Ensembl ENSG00000100453
Vega OTTHUMG00000029369
UCSC uc001wps.4
GO terms: 28 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001906 cell killing GO Biological Processes -7.45870005 11 More
GO:0001909 leukocyte mediated cytotoxicity GO Biological Processes -5.30042050 7 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002449 lymphocyte mediated immunity GO Biological Processes -8.72662877 18 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0007005 mitochondrion organization GO Biological Processes -2.05283627 29 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019835 cytolysis GO Biological Processes -3.83961894 4 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0032386 regulation of intracellular transport GO Biological Processes -4.43340887 15 More
GO:0033157 regulation of intracellular protein transport GO Biological Processes -4.35957871 12 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070269 pyroptosis GO Biological Processes -4.13020121 7 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905475 regulation of protein localization to membrane GO Biological Processes -3.01117711 17 More
GO:1905477 positive regulation of protein localization to membrane GO Biological Processes -1.94173448 10 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa04650 Natural killer cell mediated cytotoxicity KEGG Pathway -3.46704202 8 More
hsa04940 Type I diabetes mellitus KEGG Pathway -8.40921139 9 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05330 Allograft rejection KEGG Pathway -10.3501019 10 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
hexachlorophene DTC 19633659 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
granzyme B proteomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Kondo H et al. Circ J. 2009
All rights reserved: Soochow University Center for Systems Biology